【近年来获得的学术科研成果】 近年来共发表高水平研究论文85篇，出版教材1部；申请发明专利20项，授权发明专利8项，其中国际发明专利2项；主持包括国家自然科学基金、国家973项目、省产学研等在内的省部级科研项目10项；获得国家级及省部级科技奖7项，江苏省教学成果奖2项。 【近年来主要研究课题】 1、国家自然科学基金，仿肝素含糖高分子的合成、抗肿瘤转移活性及靶标蛋白的相互作用研究，21574059，2016-2019. 2、企业合作横向项目，可吸收胶原组织修复材料的研发与产业化（200万）2017-2020. 3、企业合作横向项目，可塑性人工骨修复材料的研发及产业化（200万）2017-2018. 4、江苏省产学研项目，胶原基功能化牙科填充材料的研发，BY2014023-17，2014-2016. 5、江苏省“六大人才高峰”资助项目，高活性低分子量肝素原料药和人工合成肝素类似物新型抗凝血药物研发，2014-SWYY-033，2014-2017. 6、江苏省第四期“333高层次人才培养工程”（第三层次），2011-2015. 7、江苏省科技支撑计划-社会发展项目，基于静电纺丝和酶法交联的胶原基人工皮肤的研发，SBE201077350，2010-2013. 8、国家自然科学基金，表面原位合成类肝素多糖以提高生物材料血液相容性研究，50873080，2009-2011. 9、新世纪优秀人才支持计划，新型生物医用材料的研制，NCET-10-0435，2009-2012. 【近年来主要论文代表作】 1、Yan Zhang, Mihail Barboiu*, Olof Ramström*, Jinghua Chen*. Surface-Directed Selection of Dynamic Constitutional Frameworks as an Optimized Microenvironment for Controlled Enzyme Activation. ACS Catalysis. 2020, 10: 1423-1427. 2、Xihe Zhang, Juan Zhou*, Huiyan Ying, Yuting Zhou, Jiahui Lai, Jinghua Chen*. Glycogen as a Cross-Linking Agent of Collagen and Nanohydroxyapatite To Form Hydrogels for bMSC Differentiation. ACS Sustainable Chemistry & Engineering. 2020, 8: 2106-2114. 3、Yi Liu, Rui Wang, Shayang Chen, Zhujie Xu, Qiqi Wang, Peng Yuan, Yiyi Zhou, Yan Zhang, Jinghua Chen*. Heparan sulfate loaded polycaprolactone-hydroxyapatite scaffolds with 3D printing for bone defect repair. International Journal of Biological Macromolecules. 2020, 148: 153-162. 4、Yuning Han, Bin Hu, Mingyu Wang, Yang Yang, Li Zhang, Juan Zhou* and Jinghua Chen*. pH-Sensitive Tumor-Targeted Hyperbranched System Based on Glycogen Nanoparticles for Liver Cancer Therapy. Applied Materials Today, 2020, 18, 100521. 5、Huiyan Ying, Juan Zhou, Mingyu Wang, Dandan Su, Qiaoqiao Ma, Guozhong Lv, Jinghua Chen*. In situ formed collagen-hyaluronic acid hydrogel as biomimetic dressing for promoting spontaneous wound healing. Materials Science & Engineering C-Materials for Biological Applications. 2019, 101: 487-498. 6、Shuqin Xu*, Shuyu Zhou, Baoliang Mao, Jinghua Chen*, Ziyin Zhang. Cornea-Stroma-Mimicking Films Derived from Cellulose Nanocrystal Templating Fibrous Collagen as Therapeutic Contact Lenses. ACS Sustainable Chemistry & Engineering. 2019, 7: 12248-12260. 7、Lipeng Qiu, Xiaotian Shan, Miaomiao Long, Kamel S.Ahmeda, Li Zhao, Jing Mao, HuijieZhang, Chang ling Sun, Chong zhaoYou, Guozhong Lv, JinghuaChen*. Elucidation of cellular uptake and intracellular trafficking of heparosan polysaccharide-based micelles in various cancer cells. International Journal of Biological Macromolecules. 2019, 130: 755-764. 8、Dandan Su, Juan Zhou*, Kamel S.Ahmed, Qiaoqiao Ma, Guozhong Lv, Jinghua Chen*. Fabrication and characterization of collagen-heparin-polypyrrole composite conductive film for neural scaffold. International Journal of Biological Macromolecules. 2019, 129: 895-903. 9、Huijie Zhang, Li Lai, Yalin Wang, Baoting Ye, Shuhao Deng, Airan Ding, Liping Teng, Lipeng Qiu, Jinghua Chen* .Silk Fibroin for CpG Oligodeoxynucleotide Delivery. Acs Biomaterials Science & Engineering. 2019, 5: 6082-6088. 10、Yaling Wu, Zheng Xu, Wenjing Sun, Yingyue Yang, Hui Jin, Lipeng Qiu, Jinghua Chen*, Jingxiao Chen*. Co-responsive smart cyclodextrin-gated mesoporous silica nanoparticles with ligand-receptor engagement for anti-cancer treatment. Materials Science & Engineering C-Materials for Biological Applications. 2019, 103: 109831. 11、Kamel S. Ahmed, Saied A. Hussein, Abdelmoneim H. Ali, Sameh A. Korma, Qiu Lipeng*, Chen Jinghua*. Liposome: composition, characterisation, preparation, and recent innovation in clinical applications. Journal of Drug Targeting. 2019, 27: 742-761. 12、Huijie Zhang, Ting Cheng, Li Lai, Shuhao Deng, Ruixi Yu, Lipeng Qiu, Juan Zhou, Guozhong Lu, Chunyi Zhi, Jinghua Chen*. BN nanospheres functionalized with mesoporous silica for enhancing CpG oligodeoxynucleotide-mediated cancer. Nanoscale. 2018,10: 14516-14524. 13、Juan Zhou, Huiyan Ying, Mingyu Wang, Dandan Su, Guozhong Lv, Jinghua Chen*. Dual layer collagen-GAG conduit that mimic vascular scaffold and promote blood vessel cells adhesion, proliferation and elongation. Materials science & engineering C. 2018, 92:447-452. 14、Juan Zhou, Mingyu Wang, Huiyan Ying, Dandan Su, Huijie Zhang, Guozhong Lv, Jinghua Chen*. Extracellular Matrix Component Shelled Nanoparticles as Dual Enzyme-Responsive Drug Delivery Vehicles for Cancer Therapy. ACS Biomaterials Science & Engineering. 2018, 4:2404-2411. 15、Lipeng Qiu, Lu Ge, Miaomiao Long, Qian Wang, Yan Zhang, Xiaotian Shan, Jingxiao Chen, Huijie Zhang, Xiaomei Li, Guozhong Lv， Jinghua Chen*. Designing heparan sulfate-based biocompatible polymers and their application for intracellular stimuli-sensitive drug. Materials science & engineering C. 2018, 94:465-476. 【主要授权国家发明专利】 近三年已授权： 1、硫酸化肝素二糖接枝聚甲基丙烯酰乙醇胺的用途，发明专利号，ZL201810399166.3； 2、一种硫酸化肝素二糖接枝聚甲基丙烯酰乙醇胺及其制备方法，发明专利号，ZL201810399859.2； 3、一种猪胸主动脉中提取水不溶性胶原的方法，专利号，ZL201510237801.4； 4、一种组织工程皮肤的制备方法，专利号，ZL201510410472.9； 近三年已公开： 1、 一种融合白蛋白纳米粒及其应用，公开号，PCT/CN2019/095707；201910525910.4； 2、 硫酸化肝素二糖接枝聚甲基丙烯酰乙醇胺的用途，公开号，PCT/CN2018/091470； 3、 一种硫酸化肝素二糖接枝聚甲基丙烯酰乙醇胺及其制备方法，公开号，PCT/CN2018/091475； 4、 一种羊膜-海绵状壳聚糖复合双层伤口敷料的制备方法，公开号，PCT/CN2019/122412 【主要科研奖励】 1、微生物发酵生产酸性功能多糖的关键技术与应用 轻工联合会技术进步奖二等奖 2019.2 2、酸性功能多糖发酵生产与结构调控的关键技术及应用 高等学校科学研究优秀成果奖科学技术进步奖二等奖 2019.1 3、微环境调控创面修复的关键技术及应用 江苏医学科技奖一等奖 2018.12 4、微生物制备线性糖胺聚糖及结构调控的关键技术 中国商业联合会科学技术奖一等奖 2018.12 5、生肌玉红膏及其符合改性后胶原蛋白促进慢性创面愈合系列研究 中华中医药学会科学技术奖二等奖 2017.11 6、烧创伤创面修复相关材料的基础及应用研究 江苏省科学技术奖二等奖 2017.2 |
