科学研究情况简介 |
【学科建设方面】 龚笑海教授于2014年首次发起并组织了国际生物医药产学研论坛在无锡澳门正规最大游戏平台的召开，该论坛每年邀请国际前言生物医药研究者对国际医药产业的前言进行深度剖析，对生物制药人才的培养模式具有十分重要的意义。龚笑海教授负责每年参会人员的邀请及会议的主持，随着影响力度的加大，现由江南大学、无锡市食品药品监督管理局以及无锡市对外科技交流中心共同主办，截止目前国际生物医药产学研论坛已经召开四届（2014-2017），对澳门十大电子网站网址的生物医药学科建设起到了积极导向作用。 【近年来主要及协助研究课题】 [1] PARP抑制剂类小分子与中国人胰腺癌的治疗 [2] 人BMP10活性蛋白的表达鉴定及其在心脏保护方面的应用 [3] 药物高通量筛选平台的构建-与美国Origene公司的合作 [4] 长效糖尿病治疗创新药物GLP-1的研制及产业化研究 [5] DNA修复酶PNKP与肿瘤耐药的相关性研究 【近年来辅导发表论文】 1. Chen Shuxian, Wang Xu, Ye Xianghui, Gong xiaohai, et al. Identification of human UMP/CMP kinase 1 as doxorubicin binding target using protein microarray. J Biomol Screen, 2017, 22: 1007-1015. 2. Fu Qianyun, Chen Zhen, Gong Xiaohai, et al. β-Catenin expression is regulated by an IRES-dependent mechanism and stimulated by paclitaxel in human ovarian cancer cells. Biochem and Bioph Res Co, 2015, 416: 21-27. 3. Qian Kai, Gong Xiaohai, Guan Bo, et al. Efficient expression of glucagon-like peptide-1 analogue with human serum albumin fusion protein in Pichia pastoris using the glyceraldehyde-3-phosphate dehydrogenase promoter. Biotechnol Bioproc E, 2015, 20: 694-700. 4. Qian Kai, Li Chengyuan, Gong Xiaohai, et al. Expression of a glucagon-like peptide-1 analogue, as a therapeutic agent for type II diabetes, with enhanced bioactivity and increased N-terminal homogeneity in Pichia pastoris. Biotechnol Lett, 2015, 37: 2229–2235. 5. Yang Xueli, Ndawula Jr Charles, Zhou Haiyan, Gong Xiaohai, Jin Jian. JF-305, a pancreatic cancer cell line is highly sensitive to the PARP inhibitor olaparib. Oncol lett, 2015, 9: 757-761. 6. Charles Ndawula Jr., Xueli Yang, Xiaohai Gong, Jian Jin CHK21100delC, I157T, IVS2 +IG > A, BRCA1 and BRCA2 Mutation Analysis in JF305: A Pancreatic Cancer Cell Line Journal of Biosciences and Medicines, 2014, 2, 58-67 7. Xueli Yang, Charles Ndawula, Haiyan Zhou, Xiaohai Gong, Jian Jin JF-305, a pancreatic cancer cell line is highly sensitive to the PARP inhibitor olaparib. Oncol Lett 2015 Feb 3;9(2):757-761. 8. Muhammad Imran Amirzada, Xin Ma, Xiaohai Gong, Yun Chen, Sajid Bashir, Jian Jin Recombinant human interleukin 24 reverses Adriamycin resistance in a human breast cancer cell line. Pharmacol Rep 2014 Oct 6;66(5):915-9. 9. Muhammad Imran Amirzada, Minglei Yu, Xiaohai Gong, Yun Chen, Ruiyu Zhu, Jianyong Lei, Jian Jin Cost-effective production of recombinant human interleukin 24 by lactose induction and a two-step denaturing and one-step refolding method. J Ind Microbiol Biotechnol 2014 Jan 31;41(1):135-42. 10. Haiyan Zhou, Jun Ma, Xueli Yang, Xiaohai Gong, Qiuping Li, Jian Jin Expression and purification of hPARP1 by baculovirus system. Sheng Wu Gong Cheng Xue Bao 2013 Jul;29(7):998-1005 11. Bo Guan, Jianyong Lei, Shuai Su, Fengxiang Chen, Zuoying Duan, Yun Chen, Xiaohai Gong, Huazhong Li, Jian Jin Absence of Yps7p, a putative glycosylphosphatidylinositol-linked aspartyl protease in Pichia pastoris, results in aberrant cell wall composition and increased osmotic stress resistance. FEMS Yeast Res 2012 Dec 25;12(8):969-79. 12. Robert L. Martone, Hua Zhou, Kevin Atchison, Thomas Comery, Jane Z. Xu, Xinyi Huang, Xioahai Gong, Mei Jin, Anthony Kreft, Boyd Harrison, Scott Mayer, Suzan Aschmies, Cathleen Gonzales, Margaret Zaleska, Davidc R. Riddell, Erik Wagner, Peimin Lu, Roy Sun, June Sonnenberg-Reines, Aram Oganesian, Karissa Adkins, Donna Huryn, Magid Abou-Gharbia, Ronald Magolda, Jonathan Bard, Jeffrey Paul, Glen Frick, Sangeeta Raje, S. Bradley Forlow, Carrie Balliet, Michael E. Burzynski, Peter Reinhart, Hong L. Wan, Menelas N. Pangalos, J. Steven Jacobsen* GSI-953 (Begacestat): A novel, selective thiophene sulfonamide inhibitor of APP γ-secretase for the treatment of Alzheimer’s disease Journal of Pharmacology and Experimental Therapeutics 2009, 331:598–608 13. Jie Zhang , Diana Chen , Xiaohai Gong , Huaiping Ling , Guoming Zhang , Andrew Wood , Julia Heinrich , Seongeun Cho Cyclic-AMP Response Element-Based Signaling Assays for Characterization of Trk Family Tyrosine Kinases Modulators. Neurosignals, 2006 Jul 6;15 (1): 26-39 14. Feng Liu, Xiaohai Gong, Guoming Zhang, Karen Marquis, Peter Reinhart and Terrance H. Andree The inhibition of glycogen synthase kinase 3b by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Aâ peptides. Journal of Neurochemistry, 2005, 95, 1363–1372 |
