科学研究情况简介 |
【近年来获得的学术科研成果】 主要研究方向是将动态共价键化学与生物医用材料、酶催化、生物识别等结合，开发可适应性新材料。近年来主持江苏省自然科学基金，以第一作者或通讯作者发表SCI文章20余篇，包括专业权威期刊Chemical Reviews、ACS Catalysis、Chemical Communications等，并参与部分本科生教学。 【近年来主要研究课题】 江苏省自然科学基金青年项目 江苏省“双创”博士 【近年来主要论文代表作】 期刊文章： Y. Liu, R. Wang, S. Chen, Z. Xu, Q. Wang, P. Yuan, Y. Zhou, Y. Zhang*, J. Chen*. Heparan sulfate loaded polycaprolactone-hydroxyapatite scaffolds with 3D printing for bone defect repair. Int. J. Biol. Macromol. 2020, 148, 153-162. Y. Zhang, M. Barboiu*, O. Ramstrom*, J. Chen*. Surface-directed selection of dynamic constitutional frameworks as an optimized microenvironment for controlled enzyme activation. ACS. Catal. 2020, 10, 1423-1427. Y. Zhang*, Y. Qi, S. Ulrich*, M. Barboiu*, O. Ramstrom*. Dynamic covalent polymers for biomedical applications. Mater. Chem. Front. 2020, 4, 489-506. Y. Zhang*, Y. Zhang, O. Ramstrom*. Dynamic covalent kinetic resolution. Catal. Rev. 2020, 62, 66-95. Y. Zhang, Y. Li, C. Su, M. Barboiu*, Dynameric frameworks with aggregation-induced emission (AIE) for selective detection of ATP. ChemPlusChem. 2018, 83, 506-513. Y. Zhang, C. T. Supuran, M. Barboiu*, Exponential activation of carbonic anhydrase by encapsulation in dynameric host matrices with chiral discrimination. Chem. Eur. J. 2018, 24, 715. Y. Zhang, W. Feng, Y. Legrand, C. Supuran, C. Su and M. Barboiu*. Dynameric host frameworks for the activation of lipase through H-bond and interfacial encapsulation. Chem. Commun. 2016. 52, 13768. Y. Zhang, S. Jayawardena, M. Yan, O. Ramstrom*. Enzyme classification using complex dynamic hemithioacetalsystems. Chem. Commun., 2016, 52, 5053. Y. Zhang, Y. Legrand, P. Eddy, C.Supuran, M, Barboiu*. Dynamic encapsulation and activation of carbonic anhydrase in multivalent dynameric host matrixes. Chem. Commun. 2016, 52, 4053. Y. Zhang, Y. Legrand, A. Lee, M. Barboiu*. Ligand- and metal-driven selection of flexible adaptive dynamic host receptors. Eur. J. Org. Chem. 2016, 2016, 1825. Y. Zhang, M. Barboiu*. Constitutional dynamic materials - towards natural selection of function. Chem. Rev. 2016, 116, 809. Y. Zhang, M. Barboiu*. Dynameric asymmetric membranes for directional water transport. Chem. Commun. 2015. 51, 15925. Y. Zhang, Y. Zhang, Y. Ren, O. Ramstrom*. Synthesis of chiral oxazolidinone derivatives through lipase-catalyzed kinetic resolution. J. Mol. Catal. B: Enzym. 2015, 122, 29. Y. Zhang, F. Schaufelberger, M. Sakulsombat, C. Liu and O. Ramstrom*. Asymmetric synthesis of 1,3-oxathiolan-5-one derivatives through dynamic covalent kinetic resolution. Tetrahedron 2014, 70, 3826. Y. Zhang, P. Vongvilai, M. Sakulsombat, A. Fischer and O. Ramstrom*. Asymmetric synthesis of substituted thiolanes through domino thia-Michael-Henry dynamic covalent systemic resolution using lipase catalysis. Adv. Synth. Catal. 2014, 356, 987. Y. Zhang, and O. Ramstrom*. Thiazolidinones from dynamic systemic resolution of complex reversible reaction networks. Chem. Eur. J. 2014, 20, 3288. Y. Zhang, L. Hu and O. Ramstrom*. Double parallel dynamic resolution through lipase-catalyzed asymmetric transformation. Chem. Commun. 2013, 49, 1805. 书籍章节： Y. Zhang and M. Barboiu*. Self-assembly in dynamic systems. J. Atwood, eds., Comprehensive Supramolecular Chemistry II. Elsevier, 2017. Y. Zhang, L. Hu, O. Ramstrom*. Constitutional dynamic chemistry for bioactive compounds. H.-J. Schneider, eds., Supramolecular Systems in Biomedical Fields. RSC, UK, 2013. 【主要授权国家发明专利】 【主要科研奖励】 |
